教授/研究员

金危危 教授

发布日期2024-04-16 浏览次数 信息来源

    金危危博士,教授,博士生导师,天津农学院党委副书记、校长,天津市作物学重点学科带头人,天津市主要农作物智能育种重点实验室主任。目前还担任国务院学位委员会学科评议组成员、《作物学报》副主编、Chromosome ResearchThe  Crop JournalJIASCI杂志编委等职务。近年来,已在Nature GeneticsNature CommunicationsGenome BiologyPNASPlant CellMolecular PlantNucleic Acids  ResearchNew Phytologist等国际主流SCI学术杂志发表研究论文60余篇,获得国家发明专利6项。荣获2016年度教育部技术发明奖一等奖、2017年度大北农科技奖植物育种奖、2018年度国家自然科学奖二等奖、2022年度教育部自然科学奖一等奖、2022年度北京市科学技术发明奖一等奖等多项奖励。

一、学习工作经历

1998 9 -2001 12月武汉大学博士       

2002 2 - 20066月美国威斯康星大学博士后、助理研究员;       

2006 7 - 2012 11月中国农业大学农学与生物技术学院教授;       

2012 12 - 2015 9月中国农业大学农学与生物技术学院教授/ 副院长;       

2015 10 - 202110月中国农业大学农学院教授/院长       

202110 - 202310月天津农学院,教授/校长 

202311至今天津农学院,教授/校长

二、主要任(兼)职:

国务院学位委员会学科评议组(作物学)成员

中国作物学会人才培养与教育专业委员会发展战略咨询委员

中国作物学会玉米专业委员会副会长

《作物学报》副主编

《玉米科学》编委

Chromosome Research编委

The Crop Journal编委

Reproduction and Breeding编委

Journal of Integrative Agriculture编委

玉米生物育种全国重点实验室学术委员会委员

华北作物改良与调控国家重点实验室学术委员会委员

农业部甘薯生物学与生物技术重点实验室学术委员会委员

教育部作物基因资源与遗传改良国际合作联合实验室学术委员会委员

国家现代农业与食品前沿产业技术创新联盟指导委员会委员

三、研究方向及主要成果:

1.开展玉米重要农艺性状基因克隆研究。克隆了多个产量、品质和抗逆相关基因,克隆调控玉米株型建成、成花转换和雄性不育的关键基因la1、ipe1、Sdt7、tvt1-R、dlf1等;阐明显性基因Si3引起玉米花序发育和小花性别决定紊乱的分子机制;解析hsp101和invan6介导减数分裂抗热性的重要作用(PlantPhysiol 2013, 2017,2020a, 2020b; New Phytol 2020, 2022; Plant Cell 2020, 2022)。获国家发明专利6项。

2.开展玉米单倍体诱导机理研究。结合细胞学、分子生物学和基因组学,证实玉米单倍体的染色体消除假说;参与玉米单倍体育种高效技术体系的创建(2016年度高等学校科学研究优秀成果技术发明奖,一等奖);通过单细胞测序发现单倍体诱导系花粉精核片段化现象,相关研究丰富了玉米单倍体诱导机理(PlantPhysiol 2013; Mol Plant 2017; Nat Commun 2017)

3.开展玉米等作物基因组学研究。完成薏苡基因组组装,为薏苡从头驯化提供基因组基础;揭示现代玉米中大片段PAV的摩擦禾来源,为玉米进化提供新的见解;解析了燕麦玉米附加系中单条玉米染色体的转录组和表观组变化,以此为模型阐释远缘杂交后异源基因组间的协调机制(NucleicAcids Res 2018; Mol Plant 2020; Genome Biol 2021)

4.开展鲜食玉米育种栽培及产品加工研究,选育出津糯111、津黑糯529、津农0802等多个鲜食玉米品种。

四、主持项目:

1.玉米骨干自交系深度重测序及有利基因大规模挖掘,国家863计划  

2.作物基因组学,国家杰出青年科学基金项目  

3.玉米株高基因sd7pin1subr2的调控网络解析,国家自然科学基金-重大研究计划集成项目  

4.玉米半矮秆基因Sd7sd8的克隆和功能分析,国家自然科学基金-重大研究计划重点项目  

5.玉米温敏无雄穗基因Tvt2的克隆和功能分析,国家自然科学基金-联合基金重点项目

五、开展课程:

研究生课程《作物科学研究进展》

本科生课程《现代农业与乡村振兴》、《作物育种学》

六、代表性论文:

1.Li YF,Huang YM,Sun ,Wang TY,Ru W,Pan LL,Zhao XM,Dong ZB,Huang W*,Jin WW*.Heat shock protein 101 contributes to thethermotolerance of male meiosis in maize.Plant Cell 2022,34(10):3702-3717.

2. Huang W, Li YF, Du Y, Pan LL, Huang YM, Liu HB, Zhao Y, Shi YL, Ruan YL,Dong ZB*, Jin WW*. Maize cytosolic invertase INVAN6 ensuresfaithful meiotic progression under heat stress. New phytol 2022,236(6):2172-2188.

3. Huang YM, Huang W, Meng Z, Braz GT, Li YF, Wang K, Wang H, Lai JS, JiangJM, Dong ZB*, Jin WW*. Megabase-scale presence-absence variationwith Tripsacum origin was under selection during maizedomestication and adaptation. Genome Biol 2021,22(1):237.

4. Luo HS, Meng DX, Liu HB, Xie MJ, Yin CF, Liu F, Dong ZB, Jin WW*.Ectopic expression of the transcriptional regulator silky3 causespleiotropic meristem and sex determination defects in maizeinflorescences. Plant Cell 2020, 32, 3750-3773.

5. Xie SY, Luo HB, Huang YM, Wang YX, Ru W, Shi YL, Huang W, Wang H, DongZB, Jin WW*. A Missense Mutation in a Large Subunit ofRibonucleotide Reductase Confers Temperature-Gated Tassel Formation. PlantPhysiol 2020, 184, 1979-1997.

6. Sun HY, Wang CL, Chen XY, Liu HB, Huang YM, Li SX, Dong ZB, Zhao XM, TianF*, Jin WW*. dlf1 promotes floraltransition by directly activating ZmMADS4 and ZmMADS67 inthe maize shoot apex. New Phytol 2020, 228, 1386-1400.

7. Liu HB, Shi JP, Cai ZX, Huang YM, Lv ML, Du HL, Gao Q, Zuo Y, Dong ZB,Huang W, Qin R, Liang CZ, Lai JS*, Jin WW*. Evolution andDomestication Footprints Uncovered from the Genomes of Coix. MolPlant 2020, 13, 295-308.

8. Li HC, Wang LJ, Liu MS, Dong ZB, Li QF, Fei SL, Xiang HT, Liu BS*, JinWW*. Maize Plant Architecture Is Regulated by the Ethylene BiosyntheticGene ZmACS7. Plant Physiol2020,183:1184–1199.

9. Wang GX, HeQY, Zhao H, Cai ZX, Guo N, Zong M, Han S, Liu F, Jin WW*.ChIP-cloning analysis uncovers centromere-specific retrotransposons in Brassicanigra and reveals their rapid diversification in Brassicaallotetraploids. Chromosoma 2019, 128, 119-131.

10. Tian JG,Wang CL, Xia JL, Wu LS, Xu GH, Wu WH, Li D, Qin WC, Han X, Chen QY, Jin,W, Tian, F*. Teosinte ligule allele narrows plant architecture and enhanceshigh-density maize yields. Science2019, 365, 658-664.

11. Zhang L,Luo HB, Zhao Y, Chen XY, Huang YM, Yan SS, Li SX, Liu MS, Huang W, ZhangXL, Jin WW*. Maize male sterile 33 encodesa putative glycerol-3-phosphate acyltransferase that mediates anther cuticleformation and microspore development. BMC Plant Biol 2018,18, 318.

12. Dong ZB, YuJ, Li H, Huang W, Xu L, Zhao Y, Zhang T, Xu WY, Jiang JM, Su Z*, JinWW*. Transcriptional and epigenetic adaptation of maize chromosomes inOat-Maize addition lines. Nucleic Acids Res 2018,46(10):5012-5028.

13. Meng DX,Zhao JY, Zhao C, Luo HS, Xie MJ, Liu RY, Lai JS, Zhang XL, Jin WW*. Sequentialgene activation and extensive gene imprinting during early embryo developmentin maize. Plant J 2018, 93:445-459.

14. Li X, MengD, Chen S, Luo H, Zhang Q, Jin W*, Yan J*. Single pollennucleus sequencing reveals chromosome fragmentation as a possible cause ofhaploid induction in maize. Nat Commun 2017, 8(1):991.

15. Liu C, LiX, Meng D, Zhong Y, Chen C, Dong X, Xu X, Chen B, Li W, Li L, Tian X, Zhao H,Song W, Luo H, Zhang Q, Lai J, Jin W*, Yan J*, Chen S*. A 4bpinsertion at ZmPLA1 encoding a putative phospholipase A generates haploidinduction in maize. Mol Plant 2017, 10(3):520-522.

16. Chen XY,Zhang H, Sun HY, Luo HB, Zhao L, Dong ZB, Yan SS, Zhao C, Liu RY, Xu CY, Li S,Chen HB, Jin WW*. IRREGULAR POLLEN EXINE1 is a novel factor inanther cuticle and 30 pollen exine formation. Plant Physiol 2017,173(1):307-325.

17. Huang W,Du Y, Zhao X, Jin W*. B chromosome contains active genes andimpacts the transcription of A chromosomes in maize (Zea mays L.). BMCPlant Biol 2016, 16(1):88.

18. Dong Z, Jiang C, Chen X, Zhang T, Ding L, Song W, LuoH, Lai J, Liu R, Chen H, Zhang L*, Jin W*. Maize LAZY1mediates shoot gravitropism and inflorescence development through regulatingauxin transport, auxin signaling and light response.Plant Physiol2013,163(3):1306-1322.

19. Zhao X, XuX, Xie H, Chen S, Jin W*. Fertilization and uniparentalchromosome elimination during crosses with maize haploid inducers. PlantPhysiol2013, 163(2):721-731.

20. Wang G, LiH, Cheng Z, Jin W*. A novel translocation eventleads to a recombinant stable chromosome with interrupted centromeric domainsin rice. Chromosoma 2013, 122(4):295-303.

21. Du Z, LiH, Wei Q, Zhao X, Wang C, Zhu Q, Yi X, Xu W, Liu XS*, JinW*, Su Z*. Genome-Wide Analysis of HistoneModifications: H3K4me2, H3K4me3, H3K9ac, and H3K27ac in Oryzasativa L. Japonica. Mol Plant 2013,6(5):1463-1472.

22. Li B,Choulet F, Heng Y, Hao W, Paux E, Liu Z, Yue W, Jin W*,Feuillet C*, Zhang X*. Wheatcentromeric retrotransposons: the new ones take a major role in centromericstructure. Plant J 2013, 73(6):952-965.

23. Lai JS#,Li RQ#, Xu X#, Jin WW#, Xu ML#, Zhao HL, Xiang ZK, Song WB, Ying K,...... et al. Genome-wide patterns of genetic variation among elite maizeinbred lines.Nat Genet 2010, 42:1027-1030. (# 并列第一作者)

24. HanYH, Zhang ZH, Liu CX, Liu JH, Huang SW, Jiang J, Jin WW*.Centromere repositioning in cucurbit species: Implication of the genomic impactfrom centromere activation and inactivation. Proc Natl Acad Sci USA 2009,106:14937-14941.